Actions of papaverine on intestinal smooth muscle and its inhibition of cyclic AMP and cyclic GMP phosphodiesterases.
نویسندگان
چکیده
Papaverine, a nonspecific smooth muscle relaxant, is well known to be a potent cyclic AMP phosphodiesterase inhibitor (1, 2). In recent papers (3-8) it has been reported that smooth muscle relaxing action of papaverine is likely to be mediated through an increase of cyclic AMP due to its phosphodiesterase inhibition. Recently attention has drawn to the role of cyclic GMP, which often presents physiological and pharmacological properties
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ورودعنوان ژورنال:
- Japanese journal of pharmacology
دوره 1 شماره
صفحات -
تاریخ انتشار 1976